| CAS No.: | 1114544-31-8 |
|---|---|
| Formula: | C29h28clf3n6o |
| EINECS: | 619-540-9 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Technical |
| Customization: |
|---|
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Audited Supplier Product Name: Ponatinib Hydrochloride
Synonyms: AP24534 Mono-hydrochloride;Ponatinib Mono-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride;Ponatinib hydrochloride;Ponatinib-HCl;AP24534-HCl;3-(2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl)benzamide hydrochloride;Ponatinib Hyd
CAS: 1114544-31-8
MF: C29H28ClF3N6O
MW: 569.03
EINECS: 619-540-9
Boiling point: 777.6±70.0 °C
Description:
In December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr-Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr- AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.
Usage:
Ponatinib is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product.
1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years.
2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .
3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.
4. Fast delivery: We have stock, so we can delivery quickly once payment is received.
5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.
6. Competitive prices: A discount would be given when you make a large order.
| Make an order | Please make clear what product and what quantity you need |
| Quote | Prices and Specifications details would be offered for you to consider and confirm |
| Payment ways | Bank Transfer, Western Union, Money Gram and Bitcoin |
| Delivery ways | All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) |
| Shipping address | Provide your Valid and Correct destination address info(if possible with post code, phone number). |
| Packing | Select best ways according to quantity and safety degree(Super discreet, professional and experienced) |
| Lead time | Within 8 hours upon receipt of payment |
| Package picture | Photos of package would be offered to tell apart the items |
| Tracking number | Offered once it is released |
| Shipping time | 3-7 working days (Door-to-Door) |
| After-sale service | 24/7 Online for any problems |
Our factory:
Our laboratory:
Our warehouse:
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect.
Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other areas in the world. We have established close and stable cooperative relationships with over 200 domestic pharmaceutical and chemical enterprises. With high quality and favorable price, we′ re pleased to get your inquiry and we will reply you as soon as possible.
We will continue to forge ahead and strive hard for excellence, keep on exploring and progressing to develop more high-tech products with superior quality, to satisfy increasing demand of the clients, and create more value for our partners!
Contact us!
Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei / Sales Manager
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