CAS No.: | 163451-81-8 |
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Formula: | C12h9f3n2o2 |
EINECS: | 642-273-4 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Technical |
Customization: |
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Product Name: Teriflunomide
Synonyms: A77 1726 (Teriflunomide);A 1726;Flucyamide;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;Lefluno Mide EP IMpurity B;Lefluno mide Impurity 2(Lefluno mide EP Impurity B);A-771726;A 771726;A771726
CAS: 163451-81-8
MF: C12H9F3N2O2
MW: 270.21
EINECS: 642-273-4
Melting point: 229-232°C
Boiling point: 410.8±45.0 °C
Density: 1.424±0.06 g/cm3
Storage temp.: -20°C
Appearance: White to Pale Beige Powder
Description:
Teriflunomide, which is the active metabolite of lefluno mide (a marketed drug for the treatment of rheumatoid and psoriatic arthritis), is a non?competitive and selective inhibitor of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme in the de novo synthesis of pyrimidines. Although the net effect of inhibition of DHODH by teriflunomide and its therapeutic effect in MS are not clear, it is hypothesized that by inhibiting de novo pyrimidine synthesis, the effector functions of activated lymphocytes are suppressed, thus dampening the effect of an overactive immune system.
Uses:
The active metabolite of Lefluno mide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.
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Fiona Wei
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