CAS No.: | 135159-51-2 |
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Formula: | C24h32clno6 |
EINECS: | 663-199-9 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Technical |
Customization: |
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Product Name: Sarpogrelate hydrochloride
Synonyms: Sarpogrelate-D3 HCl;4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride;Butanedioic acid, mono[2-(dimethylamino)-1-[[;ANPLAG;MCI 9042;MCI9042;MCI-9042;Sarpogrelate Hydrochloride (mixture of isomers);Anplag;Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride (9CI);Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride, (+-)-
CAS: 135159-51-2
MF: C24H32ClNO6
MW: 465.96698
EINECS: 663-199-9
Melting point: 145-148°C
Boiling point: 504.87°C
Density: 0.9801
Storage temp.: Inert atmosphere,2-8°C
Appearance: White Powder
Description:
Sarpogrelate hydrochloride, a potent and selective serotonin 5-HT2 receptor antagonist, was launched in Japan as an antithrombotic. It exhibits inhibition of ex vivo platelet aggregation stimulated by serotonin in combination with collagen and suppression of blood vessel constriction mediated by 5-HT2 in vitro. Its antithrombotic effects have been demonstrated in several in vivo experimental models including reduction of the mortality rate in acute pulmonary thromboembolic disease, arterial thrombosis, and peripheral obstructive disease. Sarpogrelate has been shown to be especially useful as an antiplatelet agent for patients with Type 2 diabetes mellitus, in whom 5-HT2mediated amplification of collageninduced platelet aggregation is significantly increased.
Uses:
Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist ress-induced hemolysis.
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Fiona Wei
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