| CAS No.: | 145040-37-5 |
|---|---|
| Formula: | C33h34n6o6 |
| EINECS: | 627-030-2 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Technical |
| Customization: |
|---|
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Audited Supplier Product Name: Candesartan cilexetil
Synonyms: 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;Candesantan Cilexetil;1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate;1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2;1-(Cyclohexyloxycarbonyloxy)ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-1H-b;1-(((cyclohexyloxy)carbonyl)oxy)ethylester,(+-)-henyl)-4-yl)methyl);1h-benzimidazole-7-carboxylicacid,2-ethoxy-1-((2'-(1h-tetrazol-5-yl)(1,1'-bip;tcv116
CAS: 145040-37-5
MF: C33H34N6O6
MW: 610.66
EINECS: 627-030-2
Melting point: 168-170°C
Boiling point: 843.3±75.0 °C
Density: 1.37±0.1 g/cm3
Storage temp.: -20°C Freezer
Appearance: White Powder
Description:
Atacand was launched in Australia, Belgium, Canada, Denmark, Finland, the Netherlands, Norway, Sweden, S. Africa and the US as an antihypertensive agent. It can be prepared from 3-nitrophthalic acid in about eight steps. Pharmacological studies have indicated Atacand is about 10-fold more potent than Losartan and has a long elimination half-life. Like losartan, Atacand is converted to its active form during GI absorption (via ester hydrolysis). It is a potent antagonist of angiotensin II type 1 receptors. This occurs through tight binding and slow dissociation, and is more potent than ACE inhibitors. It is well tolerated (can be taken by elderly and those with type II diabetes) and has no gender effects.
Uses:
1. Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor AT1 antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 AT1 in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.
2. Candesartan cilexetil can be used as pesticide and pharmaceutical intermediates.
3. It can be used as the raw material of antihypertensive drugs.
4. Candesartan is an angiotensin-receptor blocker (ARB),Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.It may be used alone or with other agents to treat hypertension. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough.
5. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years.
2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .
3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.
4. Fast delivery: We have stock, so we can delivery quickly once payment is received.
5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.
6. Competitive prices: A discount would be given when you make a large order.
| Make an order | Please make clear what product and what quantity you need |
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| Lead time | Within 8 hours upon receipt of payment |
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| Shipping time | 3-7 working days (Door-to-Door) |
| After-sale service | 24/7 Online for any problems |
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Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect.
Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other areas in the world. We have established close and stable cooperative relationships with over 200 domestic pharmaceutical and chemical enterprises. With high quality and favorable price, we′ re pleased to get your inquiry and we will reply you as soon as possible.
We will continue to forge ahead and strive hard for excellence, keep on exploring and progressing to develop more high-tech products with superior quality, to satisfy increasing demand of the clients, and create more value for our partners!
Contact us!
Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei / Sales Manager
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