CAS No.: | 698387-09-6 |
---|---|
Formula: | C30h29cln6o3 |
EINECS: | 811-237-1 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Technical |
Customization: |
---|
Suppliers with verified business licenses
Product Name: Neratinib
Synonyms: (2e)-n-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide;Neratinib(HKI-272);(2E)-N-[4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]aMino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(diMethylaMino)-2-butenaMide;neratinib;(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide;Unii-jjh94R3pwb;HKI-272; HKI272; HKI 272
CAS: 698387-09-6
MF: C30H29ClN6O3
MW: 557.04
EINECS: 811-237-1
Melting point: 185-187°C
Boiling point: 757.0±60.0 °C
Density: 1.33
Storage temp.: Refrigerator
Appearance: Pale Yellow to Yellow Powder
Description:
The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal grow factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC50 = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefiti nib . Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.
Uses:
An oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Antitumor agent
1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years.
2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .
3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.
4. Fast delivery: We have stock, so we can delivery quickly once payment is received.
5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.
6. Competitive prices: A discount would be given when you make a large order.
Make an order | Please make clear what product and what quantity you need |
Quote | Prices and Specifications details would be offered for you to consider and confirm |
Payment ways | Bank Transfer, Western Union, Money Gram and Bitcoin |
Delivery ways | All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) |
Shipping address | Provide your Valid and Correct destination address info(if possible with post code, phone number). |
Packing | Select best ways according to quantity and safety degree(Super discreet, professional and experienced) |
Lead time | Within 8 hours upon receipt of payment |
Package picture | Photos of package would be offered to tell apart the items |
Tracking number | Offered once it is released |
Shipping time | 3-7 working days (Door-to-Door) |
After-sale service | 24/7 Online for any problems |
Our factory:
Our laboratory:
Our warehouse:
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect.
Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other areas in the world. We have established close and stable cooperative relationships with over 200 domestic pharmaceutical and chemical enterprises. With high quality and favorable price, we′ re pleased to get your inquiry and we will reply you as soon as possible.
We will continue to forge ahead and strive hard for excellence, keep on exploring and progressing to develop more high-tech products with superior quality, to satisfy increasing demand of the clients, and create more value for our partners!
Contact us!
Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei
Suppliers with verified business licenses